Host immune deficiency in immune complex nephritis.
نویسندگان
چکیده
منابع مشابه
Host Immune Deficiency in Immune Complex Nephritis1
Evidence is reviewed that indicates that an immune deficiency state may underlie patients with immune complex nephritis. Studies in several laboratories provide data that show defective immune function in patients with nephritis at the following loci: defective immunoglobulin production, impaired monocyte Fc and C3b receptor function, diminished complement biosynthesis, and decreased mesangial ...
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Recent experimental studies have shown that the local b inding of circulating ant ibody with antigens existing or planted within the glomerulus can result in damage to this structure (1-6). In particular, chemically cationized proteins are able to bind to the glomerular basement membrane (GBM), act as a planted antigen, and induce in situ immune complex formation accompanied by marked proteinur...
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We report a rare cause of rapidly progressive renal failure associated with low complement, positive ANA but negative anti DS-DNA. A renal biopsy demonstrated tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane but glomerular sparing. A review of the literature and differential diagnosis are discussed.
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Interstitial immune complex nephritis in patients with systemic lupus erythematosus (SLE). Renal tissues from 45 patients with SLE nephritis, 34 patients with idiopathic membranous nephropathy (IMN) and 77 patients with minimal glomerular disease (MGD) were studied by light, immunofluorescence and electron microscopy. Interstitial nephritis characterized by focal or diffuse infiltration of infl...
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examined by immunofluorescence for the presence of glomerular immune complex deposition. Two of 23 postmor tem kidneys and 5 of 22 biopsied during staging lapa rotomies stained positively for 7-globulin and complement. None of the patients exhibited clinical evidence of glomerulonephritis and all kidneys were essentially normal histologically. Previous studies analyzing subclinical glomerular i...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1995
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v651342